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Road safety in an aging population: risk factors, assessment, interventions, and future directions
- Kaarin J. Anstey, Ranmalee Eramudugolla, Lesley A. Ross, Nicola T. Lautenschlager, Joanne Wood
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- Journal:
- International Psychogeriatrics / Volume 28 / Issue 3 / March 2016
- Published online by Cambridge University Press:
- 18 February 2016, pp. 349-356
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With the number of older drivers projected to increase by up to 70% over the next 20 years, preventing injury resulting from crashes involving older drivers is a significant concern for both policy-makers and clinicians. While the total number of fatal crashes per annum has steadily decreased since 2005 in Australia, the rate of fatalities has demonstrated an upward trend since 2010 in drivers aged 65 years and above (8.5 per 100,000), such that it is now on par with the fatality rate in drivers aged 17–25 years (8.0 per 100,000) (Austroads, 2015). Similar statistics are reported for the United States (NHTSA, 2012), implying there is a need for better identification of those older drivers who are unsafe and implementation of strategies that can enhance mobility while maximizing road safety.
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- By Frank Andrasik, Melissa R. Andrews, Ana Inés Ansaldo, Evangelos G. Antzoulatos, Lianhua Bai, Ellen Barrett, Linamara Battistella, Nicolas Bayle, Michael S. Beattie, Peter J. Beek, Serafin Beer, Heinrich Binder, Claire Bindschaedler, Sarah Blanton, Tasia Bobish, Michael L. Boninger, Joseph F. Bonner, Chadwick B. Boulay, Vanessa S. Boyce, Anna-Katharine Brem, Jacqueline C. Bresnahan, Floor E. Buma, Mary Bartlett Bunge, John H. Byrne, Jeffrey R. Capadona, Stefano F. Cappa, Diana D. Cardenas, Leeanne M. Carey, S. Thomas Carmichael, Glauco A. P. Caurin, Pablo Celnik, Kimberly M. Christian, Stephanie Clarke, Leonardo G. Cohen, Adriana B. Conforto, Rory A. Cooper, Rosemarie Cooper, Steven C. Cramer, Armin Curt, Mark D’Esposito, Matthew B. Dalva, Gavriel David, Brandon Delia, Wenbin Deng, Volker Dietz, Bruce H. Dobkin, Marco Domeniconi, Edith Durand, Tracey Vause Earland, Georg Ebersbach, Jonathan J. Evans, James W. Fawcett, Uri Feintuch, Toby A. Ferguson, Marie T. Filbin, Diasinou Fioravante, Itzhak Fischer, Agnes Floel, Herta Flor, Karim Fouad, Richard S. J. Frackowiak, Peter H. Gorman, Thomas W. Gould, Jean-Michel Gracies, Amparo Gutierrez, Kurt Haas, C.D. Hall, Hans-Peter Hartung, Zhigang He, Jordan Hecker, Susan J. Herdman, Seth Herman, Leigh R. Hochberg, Ahmet Höke, Fay B. Horak, Jared C. Horvath, Richard L. Huganir, Friedhelm C. Hummel, Beata Jarosiewicz, Frances E. Jensen, Michael Jöbges, Larry M. Jordan, Jon H. Kaas, Andres M. Kanner, Noomi Katz, Matthew S. Kayser, Annmarie Kelleher, Gerd Kempermann, Timothy E. Kennedy, Jürg Kesselring, Fary Khan, Rachel Kizony, Jeffery D. Kocsis, Boudewijn J. Kollen, Hubertus Köller, John W. Krakauer, Hermano I. Krebs, Gert Kwakkel, Bradley Lang, Catherine E. Lang, Helmar C. Lehmann, Angelo C. Lepore, Glenn S. Le Prell, Mindy F. Levin, Joel M. Levine, David A. Low, Marilyn MacKay-Lyons, Jeffrey D. Macklis, Margaret Mak, Francine Malouin, William C. Mann, Paul D. Marasco, Christopher J. Mathias, Laura McClure, Jan Mehrholz, Lorne M. Mendell, Robert H. Miller, Carol Milligan, Beth Mineo, Simon W. Moore, Jennifer Morgan, Charbel E-H. Moussa, Martin Munz, Randolph J. Nudo, Joseph J. Pancrazio, Theresa Pape, Alvaro Pascual-Leone, Kristin M. Pearson-Fuhrhop, P. Hunter Peckham, Tamara L. Pelleshi, Catherine Verrier Piersol, Thomas Platz, Marcus Pohl, Dejan B. Popović, Andrew M. Poulos, Maulik Purohit, Hui-Xin Qi, Debbie Rand, Mahendra S. Rao, Josef P. Rauschecker, Aimee Reiss, Carol L. Richards, Keith M. Robinson, Melvyn Roerdink, John C. Rosenbek, Serge Rossignol, Edward S. Ruthazer, Arash Sahraie, Krishnankutty Sathian, Marc H. Schieber, Brian J. Schmidt, Michael E. Selzer, Mijail D. Serruya, Himanshu Sharma, Michael Shifman, Jerry Silver, Thomas Sinkjær, George M. Smith, Young-Jin Son, Tim Spencer, John D. Steeves, Oswald Steward, Sheela Stuart, Austin J. Sumner, Chin Lik Tan, Robert W. Teasell, Gareth Thomas, Aiko K. Thompson, Richard F. Thompson, Wesley J. Thompson, Erika Timar, Ceri T. Trevethan, Christopher Trimby, Gary R. Turner, Mark H. Tuszynski, Erna A. van Niekerk, Ricardo Viana, Difei Wang, Anthony B. Ward, Nick S. Ward, Stephen G. Waxman, Patrice L. Weiss, Jörg Wissel, Steven L. Wolf, Jonathan R. Wolpaw, Sharon Wood-Dauphinee, Ross D. Zafonte, Binhai Zheng, Richard D. Zorowitz
- Edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Gert Kwakkel, Robert Miller, Case Western Reserve University, Ohio
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- Textbook of Neural Repair and Rehabilitation
- Published online:
- 05 May 2014
- Print publication:
- 24 April 2014, pp ix-xvi
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- By Frank Andrasik, Melissa R. Andrews, Ana Inés Ansaldo, Evangelos G. Antzoulatos, Lianhua Bai, Ellen Barrett, Linamara Battistella, Nicolas Bayle, Michael S. Beattie, Peter J. Beek, Serafin Beer, Heinrich Binder, Claire Bindschaedler, Sarah Blanton, Tasia Bobish, Michael L. Boninger, Joseph F. Bonner, Chadwick B. Boulay, Vanessa S. Boyce, Anna-Katharine Brem, Jacqueline C. Bresnahan, Floor E. Buma, Mary Bartlett Bunge, John H. Byrne, Jeffrey R. Capadona, Stefano F. Cappa, Diana D. Cardenas, Leeanne M. Carey, S. Thomas Carmichael, Glauco A. P. Caurin, Pablo Celnik, Kimberly M. Christian, Stephanie Clarke, Leonardo G. Cohen, Adriana B. Conforto, Rory A. Cooper, Rosemarie Cooper, Steven C. Cramer, Armin Curt, Mark D’Esposito, Matthew B. Dalva, Gavriel David, Brandon Delia, Wenbin Deng, Volker Dietz, Bruce H. Dobkin, Marco Domeniconi, Edith Durand, Tracey Vause Earland, Georg Ebersbach, Jonathan J. Evans, James W. Fawcett, Uri Feintuch, Toby A. Ferguson, Marie T. Filbin, Diasinou Fioravante, Itzhak Fischer, Agnes Floel, Herta Flor, Karim Fouad, Richard S. J. Frackowiak, Peter H. Gorman, Thomas W. Gould, Jean-Michel Gracies, Amparo Gutierrez, Kurt Haas, C.D. Hall, Hans-Peter Hartung, Zhigang He, Jordan Hecker, Susan J. Herdman, Seth Herman, Leigh R. Hochberg, Ahmet Höke, Fay B. Horak, Jared C. Horvath, Richard L. Huganir, Friedhelm C. Hummel, Beata Jarosiewicz, Frances E. Jensen, Michael Jöbges, Larry M. Jordan, Jon H. Kaas, Andres M. Kanner, Noomi Katz, Matthew S. Kayser, Annmarie Kelleher, Gerd Kempermann, Timothy E. Kennedy, Jürg Kesselring, Fary Khan, Rachel Kizony, Jeffery D. Kocsis, Boudewijn J. Kollen, Hubertus Köller, John W. Krakauer, Hermano I. Krebs, Gert Kwakkel, Bradley Lang, Catherine E. Lang, Helmar C. Lehmann, Angelo C. Lepore, Glenn S. Le Prell, Mindy F. Levin, Joel M. Levine, David A. Low, Marilyn MacKay-Lyons, Jeffrey D. Macklis, Margaret Mak, Francine Malouin, William C. Mann, Paul D. Marasco, Christopher J. Mathias, Laura McClure, Jan Mehrholz, Lorne M. Mendell, Robert H. Miller, Carol Milligan, Beth Mineo, Simon W. Moore, Jennifer Morgan, Charbel E-H. Moussa, Martin Munz, Randolph J. Nudo, Joseph J. Pancrazio, Theresa Pape, Alvaro Pascual-Leone, Kristin M. Pearson-Fuhrhop, P. Hunter Peckham, Tamara L. Pelleshi, Catherine Verrier Piersol, Thomas Platz, Marcus Pohl, Dejan B. Popović, Andrew M. Poulos, Maulik Purohit, Hui-Xin Qi, Debbie Rand, Mahendra S. Rao, Josef P. Rauschecker, Aimee Reiss, Carol L. Richards, Keith M. Robinson, Melvyn Roerdink, John C. Rosenbek, Serge Rossignol, Edward S. Ruthazer, Arash Sahraie, Krishnankutty Sathian, Marc H. Schieber, Brian J. Schmidt, Michael E. Selzer, Mijail D. Serruya, Himanshu Sharma, Michael Shifman, Jerry Silver, Thomas Sinkjær, George M. Smith, Young-Jin Son, Tim Spencer, John D. Steeves, Oswald Steward, Sheela Stuart, Austin J. Sumner, Chin Lik Tan, Robert W. Teasell, Gareth Thomas, Aiko K. Thompson, Richard F. Thompson, Wesley J. Thompson, Erika Timar, Ceri T. Trevethan, Christopher Trimby, Gary R. Turner, Mark H. Tuszynski, Erna A. van Niekerk, Ricardo Viana, Difei Wang, Anthony B. Ward, Nick S. Ward, Stephen G. Waxman, Patrice L. Weiss, Jörg Wissel, Steven L. Wolf, Jonathan R. Wolpaw, Sharon Wood-Dauphinee, Ross D. Zafonte, Binhai Zheng, Richard D. Zorowitz
- Edited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel, Robert H. Miller, Case Western Reserve University, Ohio
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- Textbook of Neural Repair and Rehabilitation
- Published online:
- 05 June 2014
- Print publication:
- 24 April 2014, pp ix-xvi
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- By Ghazi Al-Rawas, Vazken Andréassian, Tianqi Ao, Stacey A. Archfield, Berit Arheimer, András Bárdossy, Trent Biggs, Günter Blöschl, Theresa Blume, Marco Borga, Helge Bormann, Gianluca Botter, Tom Brown, Donald H. Burn, Sean K. Carey, Attilio Castellarin, Francis Chiew, François Colin, Paulin Coulibaly, Armand Crabit, Barry Croke, Siegfried Demuth, Qingyun Duan, Giuliano Di Baldassarre, Thomas Dunne, Ying Fan, Xing Fang, Boris Gartsman, Alexander Gelfan, Mikhail Georgievski, Nick van de Giesen, David C. Goodrich, Hoshin V. Gupta, Khaled Haddad, David M. Hannah, H. A. P. Hapuarachchi, Hege Hisdal, Kamila Hlavčová, Markus Hrachowitz, Denis A. Hughes, Günter Humer, Ruud Hurkmans, Vito Iacobellis, Elena Ilyichyova, Hiroshi Ishidaira, Graham Jewitt, Shaofeng Jia, Jeffrey R. Kennedy, Anthony S. Kiem, Robert Kirnbauer, Thomas R. Kjeldsen, Jürgen Komma, Leonid M. Korytny, Charles N. Kroll, George Kuczera, Gregor Laaha, Henny A. J. van Lanen, Hjalmar Laudon, Jens Liebe, Shijun Lin, Göran Lindström, Suxia Liu, Jun Magome, Danny G. Marks, Dominic Mazvimavi, Jeffrey J. McDonnell, Brian L. McGlynn, Kevin J. McGuire, Neil McIntyre, Thomas A. McMahon, Ralf Merz, Robert A. Metcalfe, Alberto Montanari, David Morris, Roger Moussa, Lakshman Nandagiri, Thomas Nester, Taha B. M. J. Ouarda, Ludovic Oudin, Juraj Parajka, Charles S. Pearson, Murray C. Peel, Charles Perrin, John W. Pomeroy, David A. Post, Ataur Rahman, Liliang Ren, Magdalena Rogger, Dan Rosbjerg, José Luis Salinas, Jos Samuel, Eric Sauquet, Hubert H. G. Savenije, Takahiro Sayama, John C. Schaake, Kevin Shook, Murugesu Sivapalan, Jon Olav Skøien, Chris Soulsby, Christopher Spence, R. ‘Sri’ Srikanthan, Tammo S. Steenhuis, Jan Szolgay, Yasuto Tachikawa, Kuniyoshi Takeuchi, Lena M. Tallaksen, Dörthe Tetzlaff, Sally E. Thompson, Elena Toth, Peter A. Troch, Remko Uijlenhoet, Carl L. Unkrich, Alberto Viglione, Neil R. Viney, Richard M. Vogel, Thorsten Wagener, M. Todd Walter, Guoqiang Wang, Markus Weiler, Rolf Weingartner, Erwin Weinmann, Hessel Winsemius, Ross A. Woods, Dawen Yang, Chihiro Yoshimura, Andy Young, Gordon Young, Erwin Zehe, Yongqiang Zhang, Maichun C. Zhou
- Edited by Günter Blöschl, Technische Universität Wien, Austria, Murugesu Sivapalan, University of Illinois, Urbana-Champaign, Thorsten Wagener, University of Bristol, Alberto Viglione, Technische Universität Wien, Austria, Hubert Savenije, Technische Universiteit Delft, The Netherlands
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- Runoff Prediction in Ungauged Basins
- Published online:
- 05 April 2013
- Print publication:
- 18 April 2013, pp ix-xiv
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Yoghurt and dairy snacks presented for sale to an Australian consumer: are they becoming less healthy?
- Karen Z Walker, Julie Woods, Jamie Ross, Rachel Hechtman
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- Public Health Nutrition / Volume 13 / Issue 7 / July 2010
- Published online by Cambridge University Press:
- 22 December 2009, pp. 1036-1041
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Objective
To assess the nutrient profile of yoghurts and dairy desserts.
DesignNutrition information panels and product labels on yoghurts and dairy desserts offered for sale were surveyed in 2005 and 2008 and nutrients analysed by two nutrient profiling systems.
SettingA large supermarket in metropolitan Melbourne, Australia.
ResultsIn total, 248 and 140 dairy snacks (yoghurt, fromage frais or dairy desserts) were surveyed in 2005 and 2008, respectively. Over this time, median packet size rose significantly (P ≤ 0·001). In yoghurts, median energy and total fat content also increased while protein decreased (all P < 0·05). The proportion of ‘full-fat’ products rose from 36 % to 46 %. Because of the addition of sugar, most ‘reduced-fat’ yoghurts had energy content similar to many ‘full-fat’ yoghurts. Overall, the proportion of yoghurts and dairy desserts that were ‘less healthy’ (i.e. displaying one or more ‘red traffic lights’ for high fat, saturated fat, salt and sugar content) rose from 12 % in 2005 to 23 % in 2008. Only 1–2 % could be deemed ‘healthy’ by the most stringent criterion (displaying four ‘green traffic lights’), while 21 % (2005) or 28 % (2008) were ‘healthy’ by a nutrient profiling system that included a score for protein. Sucrose, the most common sweetener, was found in levels up to 29 g/100 g. Claims on packaging mainly related to Ca, fat or protein content. Few labels referred to sugar content.
ConclusionsThe deterioration in nutrient quality of yoghurts needs to be redressed.
Contributors
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- By Nicholas B. Allen, Stephanie Assuras, Robert M. Bilder, Joan C. Borod, John L. Bradshaw, Warrick J. Brewer, Ariel Brown, Nik Brown, Tyrone Cannon, Audrey Carstensen, Cameron S. Carter, Luke Clark, Phyllis Chua, Thilo Deckersbach, Richard A. Depue, Tali Ditman, Aleksey Dumer, David E. Fleck, Lara Foland-Ross, Judith M. Ford, Nelson Freimer, Paolo Fusar-Poli, Nathan A. Gates, Terry E. Goldberg, George Graham, Igor Grant, Melissa J. Green, Michelle M. Halfacre, Wendy Heller, John D. Herrington, Garry D. Honey, Jennifer E. Iudicello, Henry J. Jackson, J. David Jentsch, Donald Kalar, Paul Keedwell, Ester Klimkeit, Nancy S. Koven, Donna A. Kreher, Gina R. Kuperberg, Edythe London, Dan I. Lubman, Daniel H. Mathalon, Patrick D. McGorry, Philip McGuire, George R. Mangun, Gregory A. Miller, Albert Newen, Jack B. Nitschke, Jaak Panksepp, Christos Pantelis, Mary Philips, Russell A. Poldrack, Scott L. Rauch, Susan M. Ravizza, Steven Paul Reise, Nicole Rinehart, Angela Rizk-Jackson, Trevor W. Robbins, Tamara A. Russell, Fred W. Sabb, Cary R. Savage, Kimberley R. Savage, J. Cobb Scott, Marc L. Seal, Larry J. Seidman, Paula K. Shear, Marisa M. Silveri, Nadia Solowij, Laura Southgate, G. Lynn Stephens, D. Stott Parker, Stephen M. Strakowski, Simon A. Surguladze, Kate Tchanturia, René Testa, Janet Treasure, Eve M. Valera, Kai Vogeley, Anthony P. Weiss, Sarah Whittle, Stephen J. Wood, Steven Paul Woods, Murat Yücel, Deborah A. Yurgelun-Todd
- Edited by Stephen J. Wood, University of Melbourne, Nicholas B. Allen, University of Melbourne, Christos Pantelis, University of Melbourne
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- Book:
- The Neuropsychology of Mental Illness
- Published online:
- 10 May 2010
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- 01 October 2009, pp xv-xx
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The effects of sowing date and other factors on growth, yield and nitrogen uptake, and on the incidence of pests and diseases, of winter barley at rothamsted from 1981 to 1983
- F. V. Widdowson, R. J. Darby, A. M. Dewar, J. P. Jenkyn, B. R. Kerry, D. W. Lawlor, R. T. Plumb, G. J. S. Ross, G. C. Scott, A. D. Todd, D. W. Wood
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- Journal:
- The Journal of Agricultural Science / Volume 106 / Issue 3 / June 1986
- Published online by Cambridge University Press:
- 27 March 2009, pp. 551-574
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Multifactorial experiments on winter barley cv. Igri grown after potatoes were made from 1981 to 1983 on silty clay loam soils at Rothamsted. All tested combinations of seven factors, each at two levels: with and without autumn pesticide (aldicarb), two sowing dates (September or October), with and without a fungicidal seed treatment (‘Baytan’), with and without spring and summer fungicides, two amounts of nitrogen, two times of applying nitrogen and with and without a growth regulator (‘Terpal’). Growth, development, yield, nitrogen uptake, pests and diseases were monitored. Sowing in September, fungicide sprays in spring and summer, and the growth regulator had the largest mean benefits on grain yield (+0·80, +0·56 and +0·34 t/ha respectively). Some factors interacted with sowing date; thus aldicarb, the fungicide sprays in spring and summer and the later timing of N all increased yield more on the September-than on the October-sown barley. The larger yields on the September-sown plots were associated with more ears/m2 (978 v. 744) and, in spite of fewer grains per ear (17·8 v. 20·1), more grains per m2 (17·6 v. 14·7 × 103), but lighter grains (39·2 v. 42·3 mg). The largest yields each year (ca. 8.0–8.5 t/ha) were obtained from September-sown barley fully protected from pests and from pathogens in spring and summer and given N in April rather than in March.
The aphid vectors of barley yellow dwarf virus were sufficiently common and infective in two of the three autumns to infect the September-sown barley sufficiently that their control by aldicar b enhanced yield. Nematodes, slugs and dipterous stem borers were not numerous enough to be damaging in any year. Mildew in autumn was controlled by the seed treatment, but effects on yield were inconsistent. Mildew in spring and summer was more abundant on the October-than on the September-sown barley; it was controlled by fungicide sprays, which increased yield significantly each year. Leaf blotch was more abundant on the September-sown barley.
Effects of seven factors on the growth and yield of winter barley grown as a third consecutive take-all susceptible crop and of growing the barley after oats or a fallow
- J. F. Jenkyn, N. Carter, R. J. Darby, R. J. Gutteridge, L. A. Mullen, R. T. Plumb, G. J. S. Ross, A. D. Todd, F. V. Widdowson, D. W. Wood
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- The Journal of Agricultural Science / Volume 119 / Issue 3 / December 1992
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- 27 March 2009, pp. 303-333
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In experiments at Rothamsted in 1984–86, seven factors, each at two levels, were tested in factorial combination on winter barley (cv. Panda) grown as a third take-all susceptible crop. The factors were seed rate, a growth regulator prior to stem extension, amounts of N in spring, ‘winter’ nitrogen, an autumn insecticide, a fungicide applied to the seed (‘Baytan’) and a programme of fungicide sprays in spring and summer. Sowing 50% more seeds than normal increased the number of ears/unit area but had no effect on mean grain yield because grains were smaller. There were, however, significant, but unexplained, interactions between seed rate and the fungicide ‘Baytan’ applied to the seed. A growth regulator applied prior to stem extension had little effect on crop growth and no significant effect on grain yield. If sufficient N was applied in April there was little benefit from applying ‘winter’ N (30 kg/ha in November and again in February/March) except in 1985 when the amount of NO3-N in the soil, measured in the previous October, was lowest. Insecticide sprays applied in autumn to control the aphid vectors of barley yellow dwarf virus (BYDV) had no significant effect on grain yield but infectivity indices were below the threshold needed for treatment in each year. On average, ‘Baytan’ applied to the seed increased grain yield by 0·28 t/ha and this was associated with decreases in the severity of take-all. Over the three years, programmes of fungicide sprays, applied during spring and summer, increased grain yield by 0·92 t/ha but the mean response was largest where most N was applied.
The experiments also allowed the importance of interactions between different agronomic factors to be examined. A combined analysis of grain yields for all three years (based on 192 plot values) showed that only six 2- or 3-factor interactions, out of the 73 estimated, were significant (P < 0·05). Two of these interactions reflected variable responses to ‘winter’ N and fungicide sprays in the three years and three of the remaining four involved ‘Baytan’.
Additional plots of barley grown after oats had little take-all and yielded 1·14 t/ha more grain than similarly treated plots grown after barley. These responses were obtained despite evidence that oat residues had adverse effects on the growth of barley seedlings. Additional plots of barley grown after a bare fallow also had little take-all and gave even larger total yields (grain plus straw) than did barley after oats but the mean yield of grain was less than after oats because more of the dry matter after a fallow was straw. In 1984, when take-all was relatively slight, plots after a fallow gave even less grain than plots after barley (−0·77 t/ha) despite producing 2·12 t/ha more dry matter in grain plus straw.
High power laser development and experimental applications to X-ray lasers, and short pulse energy transport
- M. H. Key, H. Baldis, D. Brown, M. Grande, C. Hooker, Y. Kato, C. Lewis, P. Norreys, D. O'Neill, G. Pert, S. Ramsden, C. Regan, S. Rose, I. Ross, M. Shaw, G. Tallents, E. Wooding
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- Laser and Particle Beams / Volume 8 / Issue 1-2 / January 1990
- Published online by Cambridge University Press:
- 09 March 2009, pp. 19-25
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University research in the UK with high power lasers is carried out at the SERC's Central Laser Facility with a multi-terawatt neodymium glass laser, VULCAN, and a developmental KrF laser, SPRITE. These systems are briefly described together with the design of a new KrF laser to supersede VULCAN. The new laser design, SUPERSPRITE, is based on optical and Raman multiplexing which is being developed with the present SPRITE system. The specification of SUPERSPRITE is for 3.5 kJ in 1 ns and a peak power of 300 TW in short pulses. The new technology is seen as highly cost effective in relation to neodymium glass lasers. A resume of the development of XUV lasers in the UK in collaboration with laboratories overseas is given. The work is based on laser action through recombination in highly ionized ions and recent progress includes collaborative experiments on the GEKKO XII facility in Japan which have demonstrated laser action at the shortest wavelength to date at 45 A in Mg XII. The physics of energy transport in short pulses is fundamental to the extrapolation of recombination lasers to shorter wavelengths and is being studied from a more basic standpoint using both the VULCAN and SPRITE facilities. Some details of this work are given.
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- By Donald Addington, Jean Addington, Kelly Allott, Amanda Baker, Gregor Berger, Michael Berk, Max Birchwood, Warrick J. Brewer, Peter Burnett, Tyrone Cannon, Andrew Chanen, Philippe Conus, Barbara Cornblatt, Thomas Craig, Alex Fornito, David Fowler, Shona M. Francey, John Gleeson, Susy Harrigan, Meredith Harris, Leanne Hides, Christian G. Huber, Henry J. Jackson, Anthony F. Jorm, Eóin Killackey, Joachim Klosterkötter, Martin Lambert, Tim Lambert, Shon Lewis, Don Linszen, Dan Lubman, Nellie Lucas, Craig Macneil, Ashok K. Malla, Max Marshall, Louise K. McCutcheon, Patrick D. McGorry, Catharine McNab, Maria Michail, Anthony P. Morrison, Merete Nordentoft, Ross M. G. Norman, Keith H. Nuechterlein, Christos Pantelis, Lisa J. Phillips, Richie Poulton, Paddy Power, Jo Robinson, Frauke Schultze-Lutter, Jim van Os, José Luis Vázquez-Barquero, Dennis Velakoulis, Darryl Wade, Daniel Weinberger, Durk Wiersma, Stephen J. Wood, Annemarie Wright, Murat Yücel, Alison R. Yung, Robert B. Zipursky
- Edited by Henry J. Jackson, University of Melbourne, Patrick D. McGorry
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- Book:
- The Recognition and Management of Early Psychosis
- Published online:
- 10 August 2009
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- 19 February 2009, pp xi-xvi
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Solidification of an alloy cooled from above Part 1. Equilibrium growth
- Ross C. Kerr, Andrew W. Woods, M. Grae Worster, Herbert E. Huppert
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- Journal of Fluid Mechanics / Volume 216 / July 1990
- Published online by Cambridge University Press:
- 26 April 2006, pp. 323-342
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The interaction between the solidification and convection that occurs when a melt is cooled from above is investigated in a series of three papers. In these papers we consider a two-component melt that partially solidifies to leave a buoyant residual fluid. The solid forms a mushy layer of dendritic crystals, the interstices of which accommodate the residual fluid. The heat extraction through the upper boundary, necessary to promote solidification, drives convection at high Rayleigh numbers in the melt below the mushy layer. The convection enhances the heat transfer from the melt and alters the rate of solidification. In this paper the various phenomena are studied in a series of laboratory experiments in which ice is frozen from aqueous solutions of isopropanol. The experiments are complemented by the development of a general theoretical model in which the mush is treated as a continuum phase with thermodynamic properties that are functions of the local solid fraction. The model, which is based upon principles of equilibrium thermodynamics and local conservation of heat and solute, produces results in good agreement with the experimental data. Careful comparisons between this theory and experiments suggest the need to explore non-equilibrium effects, which are investigated in Parts 2 and 3.
Solidification of an alloy cooled from above. Part 3. Compositional stratification within the solid
- Ross C. Kerr, Andrew W. Woods, M. Grae Worster, Herbert E. Huppert
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- Journal:
- Journal of Fluid Mechanics / Volume 218 / September 1990
- Published online by Cambridge University Press:
- 26 April 2006, pp. 337-354
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This is the third of a series of papers which investigates the evolution of a binary alloy that is cooled from above and releases buoyant residual fluid as one component of the alloy is preferentially incorporated within the solid. This paper focuses on the compositional zonation that is produced when the melt is completely solidified. Parts 1 and 2 considered the temperature of the cooled boundary to be greater than the eutectic temperature of the alloy so that only partial solidification of the alloy could occur. Here we extend the study by investigating the effects that arise when the cooling temperature is less than the eutectic temperature. The formation of a completely solid layer results, which extends from the cooling plate down to a mushy zone of dendritic crystals and interstitial melt. The melt below this mushy layer is convectively unstable because it is cooled from above. This generates vigorous thermal convection. Eventually the melt becomes completely solidified and a compositionally zoned solid is formed. The solid below the cooling plate is shown to be of fixed bulk composition until it reaches the depth that the interface between the mushy layer and melt occupied when the melt first became saturated. Below this level, the composition of the solid decreases with depth until it merges into the solid growing from the floor, whose composition is nearly equal to that of the heavier component of the alloy. Results of laboratory experiments with aqueous solutions of sodium sulphate are in good agreement with our quantitative predictions. The model is used to give an interpretation of profiles of the composition of magnesium oxide found within solidified komatiite lavas.
Solidification of an alloy cooled from above Part 2. Non-equilibrium interfacial kinetics
- Ross C. Kerr, Andrew W. Woods, M. Grae Worster, Herbert E. Huppert
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- Journal:
- Journal of Fluid Mechanics / Volume 217 / August 1990
- Published online by Cambridge University Press:
- 26 April 2006, pp. 331-348
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The model developed in Part 1 for the solidification and convection that occurs when an alloy is cooled from above is extended to investigate the role of disequilibrium at the mush–liquid interface. Small departures from equilibrium are important because in a convecting system an interfacial temperature below its equilibrium value can drive the bulk temperature of the melt below its liquidus. This behaviour is observed in experiments and can result in crystallization within and at the base of the convecting melt. The additional crystals formed in the interior can settle to the base of the fluid and continue to grow, causing the composition of the melt to change. This ultimately affects the solidification at the roof. The effects of disequilibrium are explored in this paper by replacing the condition of marginal equilibrium at the interface used in the model of Part 1 with a kinetic growth law of the form $\dot{h}_1 = {\cal G}\delta T$, where $\dot{h}_1$ is the rate of advance of the mush–liquid interface, δT is the amount by which the interfacial temperature is below the liquidus temperature of the melt and [Gscr ] is an empirical constant. This modification enables the model to predict very accurately both the growth of the mushy layer and the development of supersaturation in the isopropanol experiments described in Part 1. An additional series of experiments, using aqueous solutions of sodium sulphate, is presented in which the development of supersaturation leads to the internal nucleation and growth of crystals. A further extension of the model is introduced which successfully accounts for this internal crystal growth and the changing composition of the melt. We discuss the implications of this work for geologists studying the formation of igneous rocks. Important conclusions include the facts that cooling the roof of a magma chamber can lead to crystallization at its floor and that vigorous convection can occur in a magma chamber even when there is no initial superheat.
58 - Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntington's disease and other polyglutamine diseases
- from Part X - Other neurodegenerative diseases
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- By Christopher A. Ross, Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Lisa M. Ellerby, Buck Institute for Research in Aging 8001 Redwood Blvd, Novato, CA, USA, Jonathan D. Wood, University of Sheffield Academic Neurology Unit, Medical School, Sheffield, UK, Federick C. Nucifora, Jr., Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- M. Flint Beal, Cornell University, New York, Anthony E. Lang, University of Toronto, Albert C. Ludolph, Universität Ulm, Germany
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- Book:
- Neurodegenerative Diseases
- Published online:
- 04 August 2010
- Print publication:
- 02 June 2005, pp 861-870
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Summary
First description and historical review
Dentatorubral-pallidoluysian atrophy (DRPLA) was first reported by J. K. Smith in 1958, in a detailed clinical description of a single case (Smith et al., 1958). The disorder is rare in the western hemisphere, but in Japan is approximately as prevalent as Huntington's disease (HD). Like HD, DRPLA is inherited as an autosomal dominant, and shows a wide range of age of onset, with anticipation caused by instability of the triplet repeat expansion (Naito & Oyanagi, 1982; Takahashi et al., 1988; Iizuka et al., 1984; Goto et al., 1982). The triplet repeat expansion mutation which causes DRPLA was identified as part of a program to find genes with triplet repeats as candidates for neuropsychiatric disorders with anticipation (Li et al., 1993; Ross et al., 1993). Two Japanese groups independently used the primers for amplifying the CAG repeat to determine that it is expanded in DRPLA and identify the gene in which this expanded repeat is located, termed atrophin-1 (Koide et al., 1994; Nagafuchi et al., 1994; Margolis et al., 1996). The availability of a genetic test for DRPLA then made it possible to identify other families with DRPLA, some of whom had previously been diagnosed as having HD.
Morphological pattern of pathology
Among the polyglutamine neurodegenerative diseases, the pathology of DRPLA is most similar to that of HD (Ross, 1995). The areas most severely affected are given in the name of the disease. The dentate nucleus of the cerebellum has the greatest degeneration.